
法国Biospace Lab公司,是一家致力于小动物活体光学成像系统的公司,由诺贝尔奖得主Georges Charpak(乔治 查帕克)创立。Georges Charpak于1992年获诺贝尔物理学奖,以表彰他在物理粒子探测领域的突出贡献。Georges Charpak一生都致力于对物理粒子的探测,如今他所创立的Biospace Lab公司对光子的探测能力已是行业的金标准,其成像技术被广泛的应用于全球各大医药公司、研究中心等等。
另外Biospace Lab还具有创新的模块化成像方式,除了上述的5D清醒成像模块,还有3D成像模块、X光成像模块及大动物成像模块,可以根据实际需求对设备进行定制、随时随地的原地升级、任意切换模块,提供了更便捷的可选方案。
	 
	 
	 
	 
	 
	 
	 
	
研究者根据研究目的,将靶基因、靶细胞、病毒及细菌进行荧光素酶标记,同时转入动物体内形成所需的疾病模型,包括肿瘤、免疫系统疾病、感染疾病等等。可提供靶基因在体内的实时表达和对候选药物的准确反应,还可以用来评估候选药物和其它化合物的毒性。为药物在疾病中的作用机制及效用提供研究方法。
	
	
	
	 
	
5. Biospace Lab PhotonIMAGER小动物活体光学系统配置及技术指标
	 
	
	
	
	
| Year | Title | Journal | IF | |
| 2022 | Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer | Cancer Discovery | 39.3 | |
| 2017 | A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer | Nature | 38.14 | |
| 2018 | Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models | Nature Cell Biology | 28.8 | |
| 2019 | Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants | Advanced Materials | 25.809 | |
| 2018 | Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants | Advanced Materials | 25.8 | |
| 2021 | Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence | SCIENCE TRANSLATIONAL MEDICINE | 17.9 | |
| 2018 | Phenomenon of endothelial antibody capture: principles and potential for locoregional targeting of hepatic tumors | Hepatology | 17.4 | |
| 2019 | Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells | Nucleic Acids Research | 16.9 | |
| 2019 | YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib | American Journal of Respiratory and Critical Care Medicine | 16.49 | |
| 2018 | Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness | Acta Neuropathologica | 15.872 | |
| 2019 | Imaging and therapeutic applications of persistent luminescence nanomaterials | Advanced Drug Delivery Reviews | 15.606 | |
| 2018 | Imaging and therapeutic applications of persistent luminescence nanomaterials | Advanced Drug Delivery Reviews | 15.6 | |
| 2023 | CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells | Advance Science | 15.3 | |
| 2022 | The induction of peripheral trained immunity in the pancreas incites antitumor activity to control pancreatic cancer progression | nature communications | 14.9 | |
| 2022 | Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer | Nature Communications | 14.9 | |
| 2020 | Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice | Nature communications | 14.9 | |
| 2020 | Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants | Nature Communications | 14.9 | |
| 2020 | ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL | Nature Communications | 14.9 | |
| 2019 | Next-generation muscle-directed gene therapy by in silico vector design | Nature Communications | 14.9 | |
| 2018 | The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity | Nature Communications | 14.9 | |
| 2018 | MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state | Nature Communications | 14.9 | |
| 2020 | Dual targeting of G9a and DNMT1 for the treatment of experimental cholangiocarcinoma | Hepatology | 14.679 | |
| 2020 | Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer | Science advances | 14.1 | |
| 2019 | Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis | ACS Nano | 13.903 | |
| 2017 | Near-infrared dioxetane luminophores with direct chemiluminescence emission mode | Journal of the American Chemical Society | 13.86 | |
| 2021 | Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β | J Immunother Cancer | 13.7 | |
| 2018 | Mannan-induced Nos2 in macrophages enhances IL-17–driven psoriatic arthritis by innate lymphocytes | SCIENCE ADVANCES | 12.8 | |
| 2021 | Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia | Clinical Cancer Research | 12.5 | |
| 2019 | A Clinical Applicable Gene Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer | Clinical Cancer Research | 12.5 | |
| 2019 | Real-Time Monitoring of Prodrug Activation by Direct-Mode of Chemiluminescence | Angewandte Chemie | 12.257 | |
| 2021 | Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice | Theranostics | 11.5 | |
| 2020 | Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth | Theranostics | 11.5 | |
| 2020 | Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth | Theranostics | 11.5 | |
| 2018 | Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy | ACS central science | 11.2 | |
| 2021 | Antioxidant Activity and Toxicity Study of Cerium Oxide Nanoparticles Stabilized with Innovative Functional Copolymers | Advanced Healthcare Materials | 9.9 | |
| 2020 | Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models | Haematologica | 9.9 | |
| 2019 | Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL | Haematologica | 9.9 | |
| 2022 | Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51 | oncogene | 9.8 | |
| 2019 | Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway | Oncogene | 9.8 | |
| 2019 | Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F | Oncogene | 9.8 | |
| 2017 | Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice | Blood Advances | 9.782 | |
| 2019 | Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF | Cancer Immunology Research | 9.738 | |
| 2019 | Host immunity following near-infrared photoimmunotherapy is enhanced with PD-1 checkpoint blockade to eradicate established antigenic tumors | Cancer Immunology Research | 9.738 | |
| 2020 | The Ouzo effect: A tool to elaborate high-payload nanocapsules | Journal of Controlled Release | 9.7 | |
| 2019 | Pore-Forming Bioinks to Enable Spatio-Temporally Defined Gene Delivery in Bioprinted Tissues | Journal of Controlled Release | 9.7 | |
| 2019 | Liposomal dexamethasone inhibits tumor growth in an advanced humanmouse hybrid model of multiple myeloma | Journal of Controlled Release | 9.7 | |
| 2018 | Oral vitamin-A-coupled valsartan nanomedicine: High hepatic stellate cell receptors accessibility and prolonged enterohepatic residence | Journal of Controlled Release | 9.7 | |
| 2018 | Dual-Targeted Casein Micelles as Green Nanomedicine for Synergistic Phytotherapy of Hepatocellular Carcinoma | Journal of Controlled Release | 9.7 | |
| 2017 | Prediction of disease activity in models of multiple sclerosis by molecular magnetic resonance imaging of P-selectin | PNAS | 9.661 | |
| 2019 | Light emission enhancement by supramolecular complexation of chemiluminescence probes designed for bioimaging | Chemical Science | 9.556 | |
| 2019 | A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia | Cancer Research | 9.13 | |
| 2017 | Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer | Autophagy | 9.108 | |
| 2018 | Tricarbocyanine N-triazoles: the scaffold-ofchoice for long-term near-infrared imaging of immune cells in vivo† | Chemical Science | 9 | |
| 2020 | Combined CD44- and CD25-targeted Near-Infrared Photoimmunotherapy to Selectively Kill Cancer and Regulatory T cells in Syngeneic Mouse Cancer Models | Cancer immunology research | 8.619 | |
| 2017 | IL-4 primes the dynamics of breast cancer progression via DUSP4 inhibition | Cancer research | 8.556 | |
| 2019 | Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells | Oncoimmunology | 8.1 | |
| 2019 | Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo | Oncoimmunology | 8.1 | |
| 2018 | Synthesis, Characterization, and Biodistribution of Quantum Dot-Celecoxib Conjugate in Mouse Paw Edema Model | Cell Death & Differentiation | 8.1 | |
| 2018 | Clickable-Zwitterionic Copolymer Capped-Quantum Dots for in Vivo Fluorescence Tumor Imaging | ACS Applied Materials & Interfaces | 8.097 | |
| 2017 | Multimodal Hydrogel-Based Platform To Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment | ACS Cent. Sci. | 7.939 | |
| 2017 | Autophagy is required for cell survival under L-asparaginase- induced metabolic stress in acute lymphoblastic leukemia cells | Oncogene | 7.932 | |
| 2022 | Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour | Nanoscale | 7.7 | |
| 2021 | Functionalized silica nanoplatform as a bimodal contrast agent for MRI and optical imaging | Nanoscale | 7.7 | |
| 2021 | Changes in the nanoparticle uptake and distribution caused by an intramacrophagic parasitic infection | Nanoscale | 7.7 | |
| 2018 | Assessment of the targeting specificity of a fluorescent albumin conceived as a preclinical agent of the liver function | Nanoscale | 7.7 | |
| 2022 | TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy. | Frontiers in Immunology | 7.5 | |
| 2018 | Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer | Frontiers in Immunology | 7.5 | |
| 2018 | immunomodulatory Properties of carvone inhalation and its effects on contextual Fear Memory in Mice | Frontiers in Immunology | 7.5 | |
| 2017 | Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis | Journal of Controlled Release | 7.441 | |
| 2019 | Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination | Gastric Cancer | 7.3 | |
| 2018 | Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination | Gastric Cancer | 7.3 | |
| 2019 | In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT | European Journal of Nuclear Medicine and Molecular Imaging | 7.277 | |
| 2021 | Fractionated Radiation Severely Reduces the Number of CD8+ T Cells and Mature Antigen Presenting Cells Within Lung Tumors | International Journal of Radiation | 7 | |
| 2022 | Opening up new VISTAs: V-domain immunoglobulin suppressor of T cell activation (VISTA) targeted near-infrared photoimmunotherapy (NIR-PIT) for enhancing host immunity against cancers | Cancer Immunology | 6.9 | |
| 2021 | Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume | Cell Calcium | 6.8 | |
| 2019 | Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target | PLoS Pathog | 6.8 | |
| 2021 | Endoscopic near‐infrared photoimmunotherapy in an orthotopic head and neck cancer model | Cancer Science | 6.7 | |
| 2019 | Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis | EbioMedicine | 6.68 | |
| 2017 | The plasmid-encoded Ipf and Klf fimbriae display different expression and varying roles in the virulence of Salmonella enterica serovar Infantis in mouse vs. avian hosts | PLOS Pathogens | 6.608 | |
| 2022 | ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma | Molecular Oncology | 6.6 | |
| 2019 | Tumor vasculature remodeling by radiation therapy increases doxorubicin distribution and efficacy | Cancer Letters | 6.5 | |
| 2018 | Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors | Stem Cell Reports | 6.5 | |
| 2017 | Chimeric Antigen Receptor- Redirected Regulatory T Cells Suppress Experimental Allergic Airway In ammation, a Model of Asthma | Frontiers in Immunology | 6.429 | |
| 2017 | Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma | Oncotarget | 6.359 | |
| 2017 | Subcloning and characterization of highly metastatic cells derived from human esophageal squamous cell carcinoma KYSE150 cells by in vivo selection | Oncotarget | 6.359 | |
| 2020 | Regulation of T Cell Function by Reactive Nitrogen and Oxygen Species in Collagen-Induced Arthritis | Antioxidants & Redox Signaling | 6.323 | |
| 2020 | Targeting Human Lung Adenocarcinoma with a Suppressor of Mitochondrial Superoxide Production | Antioxidants & Redox Signaling | 6.323 | |
| 2021 | Impact of the chain length on the biodistribution profiles of PEGylated iron oxide nanoparticles: a multimodal imaging study | Journal of Materials Chemistry B | 6.3 | |
| 2021 | Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential | Pharmaceuticals | 6.3 | |
| 2018 | Smart Assembly of Mn-Ferrites/Silica Core-Shell with Fluorescein and Gold Nanorods: A Robust and Stable Nanomicelle for In Vivo Triple Modality Imaging. | Journal of Materials Chemistry B | 6.3 | |
| 2017 | EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth | Journal of Hematology & Oncology | 6.263 | |
| 2019 | Cytoplasmic Cyclin D1 regulates glioblastoma dissemination | The Journal of Pathology | 6.253 | |
| 2020 | Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma | Cancers | 6.126 | |
| 2020 | Interleukin-15 after Near-Infrared Photoimmunotherapy (NIR-PIT) Enhances T Cell Response against Syngeneic Mouse Tumors | Cancers | 6.126 | |
| 2020 | Combinatorial Nanomedicine Made of Squalenoyl-Gemcitabine and Edelfosine for the Treatment of Osteosarcoma | Cancers | 6.126 | |
| 2020 | Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response | Cancers | 6.126 | |
| 2020 | Preclinical Targeted α- and β−-Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies | Cancers | 6.126 | |
| 2019 | Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination | Cancers | 6.072 | |
| 2019 | What is the Best Radionuclide for Immuno-PET of Multiple Myeloma? A Comparison Study Between 89Zr- and 64Cu-Labeled Anti-CD138 in a Preclinical Syngeneic Model | International Journal of Molecular Sciences | 5.9 | |
| 2018 | Biochemical Characterization of the GBA2 c.1780G>C Missense Mutation in Lymphoblastoid Cells from Patients with Spastic Ataxia | International Journal of Molecular Sciences | 5.9 | |
| 2017 | Cerenkov radiation-induced photoimmunotherapy with 18F- FDG.” | J of nuclear medicine | 5.849 | |
| 2018 | The improvement of calvarial bone healing by durable nanogel-crosslinked materials | Journal of Biomaterials Science | 5.831 | |
| 2019 | Regulation of T Cell Function by Reactive Nitrogen and Oxygen Species in Collagen-Induced Arthritis | Antioxidants & Redox Signaling | 5.828 | |
| 2019 | Regulation of T Cell Function by Reactive Nitrogen and Oxygen Species in Collagen-Induced Arthritis | Antioxidants & Redox Signaling | 5.828 | |
| 2020 | A comparable study of polyglycolic acid's degradation on macrophages' activation | Materials Science and Engineering: C | 5.8 | |
| 2020 | Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model | International journal of pharmaceutics | 5.8 | |
| 2019 | A comparable study of polyglycolic acid’s degradation on macrophages' activation | Materials Science & Engineering C | 5.8 | |
| 2019 | Mucoadhesive thermosensitive hydrogel for the intra-tumoral delivery of immunomodulatory agents, in vivo evidence of adhesion by means of non-invasive imaging techniques | International Journal of Pharmaceutics | 5.8 | |
| 2020 | Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma | British Journal of Cancer | 5.791 | |
| 2017 | Molecularly Targeted Cancer Combination Therapy with Near Infrared Photoimmunotherapy and Near Infrared Photo-release with Duocarmycin-antibody Conjugate (RT: Combination of NIR-PIT and NIR Photo-release of Duocarmycin) | Molecular Cancer Therapeutics | 5.764 | |
| 2019 | Ingestion of polyethylene microbeads affects the growth and reproduction of medaka, Oryzias latipes | Environmental Pollution | 5.714 | |
| 2022 | Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma | Dis Model Mech | 5.7 | |
| 2021 | Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations | Dis Model Mech | 5.7 | |
| 2021 | Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo | Nutrients | 5.7 | |
| 2018 | Targeting the proteasome-associated deubiquitinating enzyme USP14 impairs melanoma cell survival and overcomes resistance to MAPK-targeting therapies | Molecular Cancer Therapeutics | 5.7 | |
| 2021 | The combination of an innovative dry powder for inhalation and a standard cisplatin-based chemotherapy in view of therapeutic intensification against lung tumours | European Journal of Pharmaceutics and Biopharmaceutics | 5.5 | |
| 2018 | A Workflow for In Vivo Evaluation of Candidate Inputs and Outputs for Cell Classifier Gene Circuits | ACS Synth. Biol | 5.4 | |
| 2022 | Radiosensitizing Fe-Au nanocapsules (hybridosomes®) increase survival of GL261 brain tumor-bearing mice treated by radiotherapy | Nanomedicine | 5.3 | |
| 2019 | A new immune-nanoplatform for promoting adaptive antitumor immune response | Nanomedicine: Nanotechnology, Biology, and Medicine | 5.3 | |
| 2018 | A new immune-nanoplatform for promoting adaptive antitumor immune response | Nanomedicine:Nanotechnology, Biology, and Medicine | 5.3 | |
| 2019 | Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors | Gene Therapy | 5.2 | |
| 2018 | Comparison of Immuno-PET of CD138 and PET imaging with 64CuCl2 and 18F-FDG in a preclinical syngeneic model of multiple myeloma | Oncotarget | 5.168 | |
| 2018 | Interstitial near-infrared photoimmunotherapy: effective treatment areas and light doses needed for use with fiber optic diffusers | Oncotarget | 5.168 | |
| 2018 | Generation and characterization of novel recombinant anti-hERG1 scFv antibodies for cancer molecular imaging | Oncotarget | 5.168 | |
| 2018 | Sensitivity of pretargeted immunoPET using 68Ga-peptide to detect colonic carcinoma liver metastases in a murine xenograft model: Comparison with 18FDG PET-CT | Oncotarget | 5.168 | |
| 2019 | Persistent Chemiluminescent Glow of Phenoxy-dioxetane Luminophore Enables Unique CRET-Based Detection of Proteases | Chem. Eur. J. | 5.16 | |
| 2018 | Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells | Oncotarget | 5.1 | |
| 2017 | IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections | J Immunol. | 4.985 | |
| 2017 | Near infrared photoimmunotherapy targeting prostate cancer with prostate-specific membrane antigen (PSMA) antibody | Molecular cancer research | 4.974 | |
| 2020 | Proliferation‐associated long noncoding RNA, TMPO‐AS1, is a potential therapeutic target for triple‐negative breast cancer | Cancer Science | 4.966 | |
| 2020 | Soluble Vegfr3 gene therapy suppresses multi‐organ metastasis in a mouse mammary cancer model | Cancer Science | 4.966 | |
| 2019 | Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex | Cancer Science | 4.966 | |
| 2019 | Near‐infrared photoimmunotherapy through bone | Cancer Science | 4.966 | |
| 2018 | Synthetic α‐mangostin dilaurate strongly suppresses wide‐spectrum organ metastasis in a mouse model of mammary cancer | Cancer Science | 4.966 | |
| 2021 | Fluorescence Imaging of Tumor-Accumulating Antibody-IR700 Conjugates Prior to Near-Infrared Photoimmunotherapy (NIR-PIT) Using a Commercially Available Camera Designed for Indocyanine Green | Molecular Pharmaceutics | 4.9 | |
| 2018 | Near infrared photoimmunotherapy with combined exposure of external and interstitial light sources | Molecular Pharmaceutics | 4.9 | |
| 2018 | Synthesis, Characterization, and Biodistribution of Quantum Dot-Celecoxib Conjugate in Mouse Paw Edema Model | Hindawi Oxidative Medicine and Cellular Longevity | 4.9 | |
| 2020 | Non-invasive in vivo imaging of acute thrombosis: development of a novel factor XIIIa radiotracer | European Heart Journal - Cardiovascular Imaging | 4.841 | |
| 2021 | G9a/GLP targeting in MM promotes autophagy-associated apoptosis and boosts proteasome inhibitor–mediated cell death | Blood Advances | 4.8 | |
| 2020 | Hepatocarcinoma Induces a Tumor Necrosis Factor-Dependent Kupffer Cell Death Pathway That Favors Its Proliferation Upon Partial Hepatectomy | Frontiers in Oncology | 4.8 | |
| 2019 | Monitoring Tuberculosis Drug Activity in Live Animals by Using Near-Infrared Fluorescence Imaging | Antimicrobial Agents and Chemotherapy | 4.715 | |
| 2020 | Inhalable Lactoferrin/Chondroitin-Functionalized Monoolein Nanocomposites for Localized Lung Cancer Targeting | ACS Biomaterials Science & Engineering | 4.511 | |
| 2020 | Inhalable Lactoferrin/Chondroitin-Functionalized Monoolein Nanocomposites for Localized Lung Cancer Targeting | ACS Biomaterials Science & Engineering | 4.511 | |
| 2021 | Clickable Radiocomplexes With Trivalent Radiometals for Cancer Theranostics: In vitro and in vivo Studies | Front. Med | 4.5 | |
| 2017 | Evaluation of early therapeutic effects after near infrared photoimmunotherapy (NIR-PIT) using luciferase-luciferin photon-counting and fluorescence imaging | Molecular Pharmaceutics | 4.44 | |
| 2018 | Cerebrospinal fluid flow increases from newborn to adult stages | Developmental Neurobiology | 4.423 | |
| 2022 | A Preliminary Study of PSMA Fluorescent Probe for Targeted luorescence Imaging of Prostate Cancer | Molecules | 4.4 | |
| 2020 | Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated 188Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor | Molecules | 4.4 | |
| 2019 | The Effect of Antibody Fragments on CD25 Targeted Regulatory T Cell Near-Infrared Photoimmunotherapy | Bioconjugate Chem | 4.349 | |
| 2020 | Bioluminescent detection of isothermal DNA amplifcation in microfuidic generated droplets and artifcial cells | Scientific reports | 4.3 | |
| 2020 | Insulin activates hepatic Wnt/β-catenin signaling through stearoyl-CoA desaturase 1 and Porcupine | Scientific reports | 4.3 | |
| 2020 | Therapeutic Efficacy of 213Bi-labeled sdAbs in a Preclinical Model of Ovarian Cancer | Molecular Pharmaceutics | 4.3 | |
| 2019 | FimH-based display of functional eukaryotic proteins on bacteria surfaces | Scientific Reports | 4.3 | |
| 2018 | Inhibition of adenovirus infection by mifepristone | Antiviral Research | 4.3 | |
| 2017 | Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques | scientific reports | 4.259 | |
| 2021 | Myeloid tumor necrosis factor and heme oxygenase-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion | I Journal of Cancer | 4.1 | |
| 2020 | Myeloid tumor necrosis factor and heme oxygenase‐1 regulate the progression of colorectal liver metastases during hepatic ischemia‐reperfusion | Int. J. Cancer. | 4.1 | |
| 2017 | Empty capsids and macrophage inhibition/depletion increase rAAV transgene expression in joints of both healthy and arthritic mice | Human gene therapy | 4.062 | |
| 2017 | Preventing Pluripotent Cell Teratoma in Regenerative Medicine Applied to Hematology Disorders | STEM CELLS TRANSLATIONAL MEDICINE | 4 | |
| 2017 | A new composite hydrogel combining the biological properties of collagen with the mechanical properties of a supramolecular scaffold for bone tissue engineering | J Tissue Eng Regen Med | 3.989 | |
| 2020 | Coating Persistent Luminescence Nanoparticles With Hydrophilic Polymers for in vivo Imaging | Front. Chem | 3.9 | |
| 2018 | ortho-Chlorination of phenoxy 1,2-dioxetane yields superior chemiluminescent probes for in vitro and in vivo imaging | Organic & Biomolecular Chemistry | 3.8 | |
| 2018 | Bimodal Fluorogenic Sensing of Matrix Proteolytic Signatures in Lung Cancer | Organic and Biomolecular Chemistry | 3.8 | |
| 2020 | Development of an LDL Receptor-Targeted Peptide Susceptible to Facilitate the Brain Access of Diagnostic or Therapeutic Agents | Biology | 3.796 | |
| 2017 | Long-term in vivo monitoring of adult-derived human liver stem/progenitor cells by BLI, PET and contrast enhanced CT” | Stem Cells and Development | 3.777 | |
| 2017 | Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice | International Journal of Pharmaceutics | 3.649 | |
| 2021 | Targeted fluorescent imaging of a novel FITC-labeled PSMA ligand in prostate cancer | Amino Acids | 3.5 | |
| 2021 | Spleen route accelerates engraftment of human hematopoietic stem cells | Biochemical and Biophysical Research Communications | 3.5 | |
| 2018 | LaAlO3:Cr3+ , Sm3+: nano-perovskite with persistent luminescence for in vivo optical imaging | Journal of Luminescence | 3.5 | |
| 2020 | Wound healing after excision of subcutaneous tumors treated with near‐infrared photoimmunotherapy | Cancer medicine | 3.362 | |
| 2017 | Tendon healing induced by chemically modified MRNAS | European Cells and Materials | 3.343 | |
| 2019 | Visualization of hydrogen polysulfdes in living cells and in vivo via a near‑infrared fuorescent probe | Journal of Biological Inorganic Chemistry | 3.3 | |
| 2020 | Near-Infrared Photoimmunotherapy Combined with CTLA4 Checkpoint Blockade in Syngeneic Mouse Cancer Models | Vaccines | 3.269 | 
	
	
	
 
             
     
 
                
                 
                     深圳市凌奥生物科技有限公司
深圳市凌奥生物科技有限公司 深圳市光明区光明街道东周社区光电北路298号灵星雨科技大厦1102
深圳市光明区光明街道东周社区光电北路298号灵星雨科技大厦1102